RENAL DISEASE IN DIABETES AND OBESITY

Description

The global increase of overweight, obesity and type 2 diabetes (T2DM) has epidemic proportions. Worldwide, more than two billion (2x109) subjects are overweight or obese and about 400 million people have diabetes, a number that will rise to 600 million by 2035. This pandemic may portend severe consequences in Nephrology. Identifying those subjects with obesity and/or diabetes at risk for renal damage is crucial. This may help optimizing preventive strategies and new treatments aiming at treating renal disease.

These objectives claim for a better understanding of the pathogenesis of diabetes- and obesity-related renal disease. A better knowledge of the causes, pathways and mechanisms of renal disease in these conditions is crucial to establish preventive strategies and treatments. Thus, the knowledge about the pathogenesis of renal damage in obesity and diabetes is crucial .

In this CME of the DOKI project, we will discuss diverse aspects of the pathogenesis of renal disease in diabetes and obesity like glomerular hyperfiltration, inflammation, renal lipotoxicity, insulin resistance, vascular disease, senescence. Also, we will discuss the patterns od evolution of renal function over time in patients with diabetic nephropathy and obesity-related renal disease.

Course content

• The clinical impact of diabetes and obesity in renal disease
• Glomerular hyperfiltration
• Insulin resistance and renal disease
• Renal lipotoxicity
• Inflammation and renal damage
• Intra-renal ischemia: a new player in diabetes and metabolic syndrome
• Patterns of renal function loss in diabetes and obesity
• Renal morphology
• Lessons from animal models